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The newest cocktail involving Phentermine is "Phen-Pro" - the "Pro" standing for Prozac. Any one of the following antidepressants: Zoloft, Celexa, Luvox, Trazadone or Effexor may be used in lieu of Prozac.
The use of the antidepressant in the Phen-Pro cocktail is unrelated to depression. The cocktail is necessary because the effects of Phentermine, when used alone, lessen over time. The Phen-Pro cocktail enables Phentermine to work better and for a longer period of time. The cocktail does not appear to cause the problems that resulted from the usage of Fen-Phen.
The combination of Phentermine and Prozac is considered an "off-label" use, meaning that the FDA, who often voice concerns regarding the mixing/combining of medications, does not approve it. However, once the agency has approved a drug, doctors may prescribe it at will.
 
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